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Bioinformatics Vol. 17 no. 3 2001
Pages 286-287
© 2001 Oxford University Press

Applications Note

Dynamic simulation of the human red blood cell metabolic network

Neema Jamshidi 1, Jeremy S. Edwards 2,3, Tom Fahland 1, George M. Church 2 and Bernhard O. Palsson 1

1 Department of Bioengineering, University of California—San Diego, La Jolla, CA 92093, USA
2 Department of Genetics, Harvard Medical School, Boston, MA 02115, USA
3 Department of Chemical Engineering, University of Delaware, Newark, DE 19711, USA

Received on June 20, 2000 ; accepted on October 6, 2000

Summary: We have developed a Mathematica®application package to perform dynamic simulations of the red blood cell (RBC) metabolic network. The package relies on, and integrates, many years of mathematical modeling and biochemical work on red blood cell metabolism. The extensive data regarding the red blood cell metabolic network and the previous kinetic analysis of all the individual components makes the human RBC an ideal ‘model’ system for mathematical metabolic models. The Mathematica package can be used to understand the dynamics and regulatory characteristics of the red blood cell.

Availability: The Mathematica package and an example file can be downloaded from http://gcrg.ucsd.edu


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