Bioinformatics Vol. 19 no. 1 2003
Pages 163-164
© 2003 Oxford University Press
Applications Note |
ConSurf: Identification of Functional Regions in Proteins by Surface-Mapping of Phylogenetic Information
1 The George S. Wise Faculty of Life Sciences,
Tel Aviv University, Ramat Aviv 69978, Israel
2 The Institute of Statistical Mathematics,
4-6-7 Minami-Azabu, Minato-ku, Tokyo 106-8569, Japan
3 Department of Microbiology, University of Massachusetts,
Amherst MA, USA
Received on March 24, 2002
; revised on July 16, 2002
; accepted on July 20, 2002
Summary: We recently developed algorithmic tools for the identification of functionally important regions in proteins of known three dimensional structure by estimating the degree of conservation of the amino-acid sites among their close sequence homologues. Projecting the conservation grades onto the molecular surface of these proteins reveals patches of highly conserved (or occasionally highly variable) residues that are often of important biological function. We present a new web server, ConSurf, which automates these algorithmic tools. ConSurf may be used for high-throughput characterization of functional regions in proteins.
Availability: The ConSurf web server is available at:http://consurf.tau.ac.il.
Contact: fabian{at}ashtoret.tau.ac.il tal{at}ism.ac.jp inbalp{at}ashtoret.tau.ac.il rebell{at}ashtoret.tau.ac.ildalit{at}ashtoret.tau.ac.il emartz{at}microbio.umass.edu bental{at}ashtoret.tau.ac.il
Supplementary Information: A set of examples is available at http://consurf.tau.ac.il under ‘GALLERY’.
* To whom correspondence should be addressed.
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