Skip Navigation

This Article
Right arrow FREE Full Text (Print PDF) Freely available
Right arrow FREE Full Text (Screen PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (8)
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Zhang, L.
Right arrow Articles by Xu, Y.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Zhang, L.
Right arrow Articles by Xu, Y.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Bioinformatics Vol. 19 no. 12 2003
Pages 1497-1504
© 2003 Oxford University Press

Greedy method for inferring tandem duplication history

Louxin Zhang 1,*, Bin Ma 2, Lusheng Wang 3 and Ying Xu 4

1 Department of Mathematics, National University of Singapore, Singapore
2 Department of Computer Science, University of Western Ontario, Canada N6A 5B8
3 Department of Computer Science, City University of Hong Kong, Hong Kong
4 Department of Computer Science, Peking University, People’s Republic of China

Received on November 4, 2002 ; revised on November 18, 2002 ; accepted on February 18, 2003

Motivation: Genome analysis suggests that tandem duplication is an important mode of evolutionary novelty by permitting one copy of each gene to drift and potentially to acquire a new function. With more and more genomic sequences available, reconstructing duplication history has received extensive attention recently.

Results: An efficient method is presented for inferring the duplication history of tandemly repeated sequences based on the model proposed by Fitch (1977). We validate the method by using simulation results and real data sets of mucin genes, ZNF genes, and olfactory receptors genes. The agreement with conclusions drawn by other biological researchers strongly indicates that our method is efficient and robust.

Availability:The program is available by request.

Contact: matzlx{at}nus.edu.sg

* To whom correspondence should be addressed.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 J. Virol.Home page
K. Suhre
Gene and Genome Duplication in Acanthamoeba polyphaga Mimivirus
J. Virol., November 15, 2005; 79(22): 14095 - 14101.
[Abstract] [Full Text] [PDF]

Home page
 Mol Biol EvolHome page
J. Yang and L. Zhang
On Counting Tandem Duplication Trees
Mol. Biol. Evol., June 1, 2004; 21(6): 1160 - 1163.
[Full Text] [PDF]


Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.