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Fig. 5 Fundamental events in the evolution of multifunction, multi-exonic proteins based on a single recognition sequence. (A) Cleavage. The sequence CAGGUG functions as the signal sequence for cleavage while the actual recognition takes place via the same sequence of a ribozyme using canonical (GC and UA) base pairing, possibly combined with non-canonical GG pairing. (B) Cleavage and in cis religation. On the basis of an anti-parallel arrangement of recognition sites, splicing could be accomplished by a cleavage of the two recognition sites followed by a religation between opposing strands. (C) Cleavage and in trans religation. A religation between different RNA strands leads to a recombination of exons modules.
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