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Bioinformatics Vol. 16 no. 7 2000
Pages 639-649
© 2000 Oxford University Press

Original Paper

Digital reviews in molecular biology: approaches to structured digital publication

D. L. Steffen 1,2, A. E. Levine 3, S. Yarus 4, R. A. Baasiri 4 and D. A. Wheeler 5

1 Biomedical Computing, Inc., Houston, TX 77005, USA
2 Department of Cell Biology and Division of Molecular Virology, Baylor College of Medicine, Houston, TX 77030, USA
3 Department of Basic Sciences, University of Texas Health Science Center, Houston, Dental Branch, Houston TX 77225, USA
4 Department of Cell Biology, Baylor College of Medicine, Houston, TX 77030, USA
5 Department of Cell Biology and Information Technology Program, Baylor College of Medicine, Houston, TX 77030, USA

Received on May 13, 1999 ; revised on December 3, 1999 ; accepted on February 15, 2000

Motivation: It is widely appreciated that it is no longer possible for biomedical research scientists to keep up with as much of what is published in their field as they ought. One solution to this problem is to increase the efficiency of information use by moving away from the classical browsing model for scientific information dissemination towards an information on demand model which would allow researchers to access information quickly and efficiently only as they need it. The most common approach to this goal has been to use information retrieval technology to improve access to text databases of biomedical information. We are interested in exploring an alternative; encoding this information for storage in structured databases for efficient retrieval.

Results: Two small databases described here are test beds for development of structured digital publication software; the Tumor Gene Database, containing information about genes which are the sites for cancer-causing mutations, and the Mammary Transgene Database, containing information about expression of transgenes in agriculturally important animals. Both have been successfully searched by users and edited by curators via the World Wide Web.

Availability: These databases can be accessed at http:// www.tumor-gene.org/drmb.html

Contact: For further information on these databases, contact the individual database owners, listed on the page above, or David Steffen, Biomedical Computing, Inc., 6626 Westchester, Houston, Texas 77005, steffen{at}biomedcomp.com


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