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Bioinformatics Vol. 17 no. 4 2001
Pages 373-374
© 2001 Oxford University Press

Applications Note

Mocca: semi-automatic method for domain hunting

Cédric Notredame

Information Genetique et Structurale, CNRS-UMR 1889, 31 Ch. Joseph Aiguier, 13 402 Marseille, France

Received on September 15, 2000 ; revised on November 30, 2000 ; accepted on December 4, 2000

Motivation: Multiple OCCurrences Analysis (Mocca) is a new method for repeat extraction. It is based on the T-Coffee package (Notredame et al. , JMB , 302, 205–217, 2000). Given a sequence or a set of sequences, and a library of local alignments, Mocca extracts every segment of sequence homologous to a pre-specified master. The implementation is meant for domain hunting and makes it fast and easy to test for new boundaries or extend known repeats in an interactive manner. Mocca is designed to deal with highly divergent protein repeats (less than 30% amino acid identity) of more than 30 amino acids.

Availability: Mocca is available on request (cedric.notredame{at}europe.com). The software is free of charge and comes with complete documentation.


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